A mathematical model for breath gas analysis of volatile organic compounds with special emphasis on acetone

Julian King, Karl Unterkofler, Gerald Teschl, Susanne Teschl, Helin Koc, Hartmann Hinterhuber, Anton Amann

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

Abstract

Recommended standardized procedures for determining exhaled lower respiratory nitric oxide and nasal nitric oxide (NO) have been developed by task forces of the European Respiratory Society and the American Thoracic Society. These recommendations have paved the way for the measurement of nitric oxide to become a diagnostic tool for specific clinical applications. It would be desirable to develop similar guidelines for the sampling of other trace gases in exhaled breath, especially volatile organic compounds (VOCs) which may reflect ongoing metabolism. The concentrations of water-soluble, blood-borne substances in exhaled breath are influenced by: (i) breathing patterns affecting gas exchange in the conducting airways, (ii) the concentrations in the tracheo-bronchial lining fluid, (iii) the alveolar and systemic concentrations of the compound. The classical Farhi equation takes only the alveolar concentrations into account. Real-time measurements of acetone in end-tidal breath under an ergometer challenge show characteristics which cannot be explained within the Farhi setting. Here we develop a compartment model that reliably captures these profiles and is capable of relating breath to the systemic concentrations of acetone. By comparison with experimental data it is inferred that the major part of variability in breath acetone concentrations (e.g., in response to moderate exercise or altered breathing patterns) can be attributed to airway gas exchange, with minimal changes of the underlying blood and tissue concentrations. Moreover, the model illuminates the discrepancies between observed and theoretically predicted blood-breath ratios of acetone during resting conditions, i.e., in steady state. Particularly, the current formulation includes the classical Farhi and the Scheid series inhomogeneity model as special limiting cases and thus is expected to have general relevance for a wider range of blood-borne inert gases. The chief intention of the present modeling study is to provide mechanistic relationships for further investigating the exhalation kinetics of acetone and other water-soluble species. This quantitative approach is a first step towards new guidelines for breath gas analyses of volatile organic compounds, similar to those for nitric oxide.

Originalspracheenglisch
Seiten (von - bis)959-999
Seitenumfang41
FachzeitschriftJournal of Mathematical Biology
Jahrgang63
Ausgabenummer5
DOIs
PublikationsstatusVeröffentlicht - 1 Nov 2011

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Volatile Organic Compounds
Gas fuel analysis
volatile organic compounds
Acetone
Volatile organic compounds
acetone
Nitric oxide
Theoretical Models
mathematical models
Gases
Nitric Oxide
gases
nitric oxide
Mathematical Model
Mathematical models
Blood
pulmonary gas exchange
breathing
blood
Gas Exchange

Schlagwörter

    ASJC Scopus subject areas

    • !!Modelling and Simulation
    • !!Agricultural and Biological Sciences (miscellaneous)
    • Angewandte Mathematik

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    A mathematical model for breath gas analysis of volatile organic compounds with special emphasis on acetone. / King, Julian; Unterkofler, Karl; Teschl, Gerald; Teschl, Susanne; Koc, Helin; Hinterhuber, Hartmann; Amann, Anton.

    in: Journal of Mathematical Biology, Jahrgang 63, Nr. 5, 01.11.2011, S. 959-999.

    Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

    King, Julian ; Unterkofler, Karl ; Teschl, Gerald ; Teschl, Susanne ; Koc, Helin ; Hinterhuber, Hartmann ; Amann, Anton. / A mathematical model for breath gas analysis of volatile organic compounds with special emphasis on acetone. in: Journal of Mathematical Biology. 2011 ; Jahrgang 63, Nr. 5. S. 959-999.
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    AU - Koc, Helin

    AU - Hinterhuber, Hartmann

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