A concise review of significantly modified serological biomarkers in giant cell arteritis, as detected by different methods

B Burja, T Kuret, S Sodin-Semrl, K Lakota, Ž Rotar, R Ješe, K Mrak-Poljšak, P Žigon, G G Thallinger, J Feichtinger, S Čučnik, M Tomšič, S Praprotnik, A Hočevar

    Publikation: Beitrag in einer FachzeitschriftArtikelBegutachtung

    Abstract

    Giant cell arteritis (GCA) is a primary systemic vasculitis present in subjects older than 50years with involvement of large- and medium-sized arteries. Early diagnosis for GCA is essential to prevent serious complications, such as permanent vision loss and/or cerebrovascular events. Elevated inflammatory cytokines, with acute phase and other proteins dominate large- and medium-sized arteries leading to stenosis or occlusion of arterial lumen. To date, there are no reliable serological markers for monitoring GCA. The review aims to provide concise overview of published GCA studies in order to: a) identify significantly changed serological biomarkers in GCA and compare the influences of techniques for marker evaluation and b) investigate most promising markers in GCA using analyte frequency and meta-analysis.

    Originalspracheenglisch
    Seiten (von - bis)188-194
    FachzeitschriftAutoimmunity Reviews
    Jahrgang17
    Ausgabenummer2
    Frühes Online-Datum28 Nov. 2017
    DOIs
    PublikationsstatusVeröffentlicht - 1 Feb. 2018

    Fields of Expertise

    • Human- & Biotechnology
    • Information, Communication & Computing

    Treatment code (Nähere Zuordnung)

    • Basic - Fundamental (Grundlagenforschung)
    • Experimental

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