A concise review of significantly modified serological biomarkers in giant cell arteritis, as detected by different methods

B Burja, T Kuret, S Sodin-Semrl, K Lakota, Ž Rotar, R Ješe, K Mrak-Poljšak, P Žigon, G G Thallinger, J Feichtinger, S Čučnik, M Tomšič, S Praprotnik, A Hočevar

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

Abstract

Giant cell arteritis (GCA) is a primary systemic vasculitis present in subjects older than 50years with involvement of large- and medium-sized arteries. Early diagnosis for GCA is essential to prevent serious complications, such as permanent vision loss and/or cerebrovascular events. Elevated inflammatory cytokines, with acute phase and other proteins dominate large- and medium-sized arteries leading to stenosis or occlusion of arterial lumen. To date, there are no reliable serological markers for monitoring GCA. The review aims to provide concise overview of published GCA studies in order to: a) identify significantly changed serological biomarkers in GCA and compare the influences of techniques for marker evaluation and b) investigate most promising markers in GCA using analyte frequency and meta-analysis.

Originalspracheenglisch
Seiten (von - bis)188-194
FachzeitschriftAutoimmunity Reviews
Jahrgang17
Ausgabenummer2
Frühes Online-Datum28 Nov 2017
DOIs
PublikationsstatusVeröffentlicht - 1 Feb 2018

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Giant Cell Arteritis
Biomarkers
Arteries
Systemic Vasculitis
Acute-Phase Proteins
Meta-Analysis
Early Diagnosis
Pathologic Constriction
Cytokines

Schlagwörter

    Fields of Expertise

    • Human- & Biotechnology
    • Information, Communication & Computing

    Treatment code (Nähere Zuordnung)

    • Basic - Fundamental (Grundlagenforschung)
    • Experimental

    Dies zitieren

    A concise review of significantly modified serological biomarkers in giant cell arteritis, as detected by different methods. / Burja, B; Kuret, T; Sodin-Semrl, S; Lakota, K; Rotar, Ž; Ješe, R; Mrak-Poljšak, K; Žigon, P; Thallinger, G G; Feichtinger, J; Čučnik, S; Tomšič, M; Praprotnik, S; Hočevar, A.

    in: Autoimmunity Reviews, Jahrgang 17, Nr. 2, 01.02.2018, S. 188-194.

    Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

    Burja, B, Kuret, T, Sodin-Semrl, S, Lakota, K, Rotar, Ž, Ješe, R, Mrak-Poljšak, K, Žigon, P, Thallinger, GG, Feichtinger, J, Čučnik, S, Tomšič, M, Praprotnik, S & Hočevar, A 2018, 'A concise review of significantly modified serological biomarkers in giant cell arteritis, as detected by different methods' Autoimmunity Reviews, Jg. 17, Nr. 2, S. 188-194. https://doi.org/10.1016/j.autrev.2017.11.022
    Burja, B ; Kuret, T ; Sodin-Semrl, S ; Lakota, K ; Rotar, Ž ; Ješe, R ; Mrak-Poljšak, K ; Žigon, P ; Thallinger, G G ; Feichtinger, J ; Čučnik, S ; Tomšič, M ; Praprotnik, S ; Hočevar, A. / A concise review of significantly modified serological biomarkers in giant cell arteritis, as detected by different methods. in: Autoimmunity Reviews. 2018 ; Jahrgang 17, Nr. 2. S. 188-194.
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    AU - Kuret, T

    AU - Sodin-Semrl, S

    AU - Lakota, K

    AU - Rotar, Ž

    AU - Ješe, R

    AU - Mrak-Poljšak, K

    AU - Žigon, P

    AU - Thallinger, G G

    AU - Feichtinger, J

    AU - Čučnik, S

    AU - Tomšič, M

    AU - Praprotnik, S

    AU - Hočevar, A

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    N2 - Giant cell arteritis (GCA) is a primary systemic vasculitis present in subjects older than 50years with involvement of large- and medium-sized arteries. Early diagnosis for GCA is essential to prevent serious complications, such as permanent vision loss and/or cerebrovascular events. Elevated inflammatory cytokines, with acute phase and other proteins dominate large- and medium-sized arteries leading to stenosis or occlusion of arterial lumen. To date, there are no reliable serological markers for monitoring GCA. The review aims to provide concise overview of published GCA studies in order to: a) identify significantly changed serological biomarkers in GCA and compare the influences of techniques for marker evaluation and b) investigate most promising markers in GCA using analyte frequency and meta-analysis.

    AB - Giant cell arteritis (GCA) is a primary systemic vasculitis present in subjects older than 50years with involvement of large- and medium-sized arteries. Early diagnosis for GCA is essential to prevent serious complications, such as permanent vision loss and/or cerebrovascular events. Elevated inflammatory cytokines, with acute phase and other proteins dominate large- and medium-sized arteries leading to stenosis or occlusion of arterial lumen. To date, there are no reliable serological markers for monitoring GCA. The review aims to provide concise overview of published GCA studies in order to: a) identify significantly changed serological biomarkers in GCA and compare the influences of techniques for marker evaluation and b) investigate most promising markers in GCA using analyte frequency and meta-analysis.

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