A blood–brain penetrant RNA-targeted small molecule triggers elimination of r(G4C2)exp in c9ALS/FTD via the nuclear RNA exosome

Jessica A. Bush; Samantha M. Meyer; Rita Fürst; Yuquan Tong; Yue Li; Raphael I. Benhamou; Haruo Aikawa; Patrick R. A. Zanon; Quentin M. R.  Gibaut; Alicia J. Angelbello; Tania F. Gendron; Yongjie Zhang; Leonard Petrucelli; Torben Heick Jensen; Jessica L. Childs-Disney; Matthew D. Disney

doi:https://doi.org/10.1073/pnas.2210532119

A blood–brain penetrant RNA-targeted small molecule triggers elimination of r(G4C2)exp in c9ALS/FTD via the nuclear RNA exosome

Jessica A. Bush, Samantha M. Meyer, Rita Fürst, Yuquan Tong, Yue Li, Raphael I. Benhamou, Haruo Aikawa, Patrick R. A. Zanon, Quentin M. R. Gibaut, Alicia J. Angelbello, Tania F. Gendron, Yongjie Zhang, Leonard Petrucelli, Torben Heick Jensen, Jessica L. Childs-Disney, Matthew D. Disney^*

^*Korrespondierende/r Autor/-in für diese Arbeit

Institut für Organische Chemie (6410)

Publikation: Beitrag in einer Fachzeitschrift › Artikel › Begutachtung

Originalsprache	englisch
Fachzeitschrift	Proceedings of the National Academy of Sciences of the United States of America
Jahrgang	2022
Ausgabenummer	119
DOIs	https://doi.org/10.1073/pnas.2210532119
Publikationsstatus	Veröffentlicht - 21 Nov. 2022

Zugriff auf Dokument

https://doi.org/10.1073/pnas.2210532119

Dieses zitieren

Bush, J. A., Meyer, S. M., Fürst, R., Tong, Y., Li, Y., Benhamou, R. I., Aikawa, H., Zanon, P. R. A., Gibaut, Q. M. R., Angelbello, A. J., Gendron, T. F., Zhang, Y., Petrucelli, L., Jensen, T. H., Childs-Disney, J. L., & Disney, M. D. (2022). A blood–brain penetrant RNA-targeted small molecule triggers elimination of r(G4C2)exp in c9ALS/FTD via the nuclear RNA exosome. Proceedings of the National Academy of Sciences of the United States of America, 2022(119). https://doi.org/10.1073/pnas.2210532119

A blood–brain penetrant RNA-targeted small molecule triggers elimination of r(G4C2)exp in c9ALS/FTD via the nuclear RNA exosome. / Bush, Jessica A.; Meyer, Samantha M.; Fürst, Rita et al.
in: Proceedings of the National Academy of Sciences of the United States of America, Jahrgang 2022, Nr. 119, 21.11.2022.

Publikation: Beitrag in einer Fachzeitschrift › Artikel › Begutachtung

Bush, JA, Meyer, SM, Fürst, R, Tong, Y, Li, Y, Benhamou, RI, Aikawa, H, Zanon, PRA, Gibaut, QMR, Angelbello, AJ, Gendron, TF, Zhang, Y, Petrucelli, L, Jensen, TH, Childs-Disney, JL & Disney, MD 2022, 'A blood–brain penetrant RNA-targeted small molecule triggers elimination of r(G4C2)exp in c9ALS/FTD via the nuclear RNA exosome', Proceedings of the National Academy of Sciences of the United States of America, Jg. 2022, Nr. 119. https://doi.org/10.1073/pnas.2210532119

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author = "Bush, {Jessica A.} and Meyer, {Samantha M.} and Rita F{\"u}rst and Yuquan Tong and Yue Li and Benhamou, {Raphael I.} and Haruo Aikawa and Zanon, {Patrick R. A.} and Gibaut, {Quentin M. R.} and Angelbello, {Alicia J.} and Gendron, {Tania F.} and Yongjie Zhang and Leonard Petrucelli and Jensen, {Torben Heick} and Childs-Disney, {Jessica L.} and Disney, {Matthew D.}",

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AU - Tong, Yuquan

AU - Li, Yue

AU - Benhamou, Raphael I.

AU - Aikawa, Haruo

AU - Zanon, Patrick R. A.

AU - Gibaut, Quentin M. R.

AU - Angelbello, Alicia J.

AU - Gendron, Tania F.

AU - Zhang, Yongjie

AU - Petrucelli, Leonard

AU - Jensen, Torben Heick

AU - Childs-Disney, Jessica L.

AU - Disney, Matthew D.

PY - 2022/11/21

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DO - https://doi.org/10.1073/pnas.2210532119

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VL - 2022

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

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