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• (Altdaten) Vortrag oder Präsentation

  Chemoenzymatic synthesis of enantiopure benzylisoquinoline and berbine alkaloids

  Schrittwieser, J., Resch, V., Sattler, J., Lienhart, W-D., Winkler, A., Macheroux, P. & Kroutil, W., 28 Feb 2011.

  Publikation: Konferenzbeitrag › (Altdaten) Vortrag oder Präsentation
• Artikel

  Applications of hydrogen deuterium exchange (HDX) for the characterization of conformational dynamics in light-activated photoreceptors

  Lindner, R., Heintz, U. & Winkler, A., 2015, in : Frontiers in Molecular Biosciences . 2, 33, S. 1-13

  Publikation: Beitrag in einer Fachzeitschrift › Artikel

• Asymmetric activation mechanism of a homodimeric red light-regulated photoreceptor

  Gourinchas, G., Heintz, U. & Winkler, A., 5 Jun 2018, in : eLife. 7, e34815.

  Publikation: Beitrag in einer Fachzeitschrift › Artikel

  Open Access

  • Phytochrome
  • Chemical activation
  • Light
  • Optogenetics
  • Signal transduction

• A ternary AppA-PpsR-DNA complex mediates light regulation of photosynthesis-related gene expression

  Winkler, A., Heintz, U., Lindner, R., Reinstein, J., Shoeman, R. L. & Schlichting, I., 2013, in : Nature structural & molecular biology. 20, S. 859-867

  Publikation: Beitrag in einer Fachzeitschrift › Artikel

• Biocatalytic enantioselective oxidative C-C coupling by aerobic C-H activation of N-CH3 to yield novel berberine alkaloid derivatives

  Schrittwieser, J. H., Resch, V., Sattler, J., Lienhart, W-D., Durchschein, K., Winkler, A., Gruber, K., Macheroux, P. & Kroutil, W., 2011, in : Angewandte Chemie / International Edition . 50, S. 1068-1071

  Publikation: Beitrag in einer Fachzeitschrift › Artikel

• Biokatalytische enantioselektive oxidative C-C-Kupplung durch C-H-Aktivierung mit molekularem Sauerstoff

  Schrittwieser, J. H., Resch, V., Sattler, J., Lienhart, W-D., Durchschein, K., Winkler, A., Gruber, K., Macheroux, P. & Kroutil, W., 2011, in : Angewandte Chemie. 123, 5, S. 1100-1103

  Publikation: Beitrag in einer Fachzeitschrift › Artikel

• Catalytic and structural role of a conserved active site histidine in berberine bridge enzyme

  Wallner, S., Winkler, A., Riedl, S., Dully, C., Horvath, S., Gruber, K. & Macheroux, P., 2012, in : Biochemistry. 51, S. 6139-6147

  Publikation: Beitrag in einer Fachzeitschrift › Artikel

• Characterization of Elements Involved in Allosteric Light Regulation of Phosphodiesterase Activity by Comparison of Different Functional BlrP1 States

  Winkler, A., Udvarhelyi, A., Hartmann, E., Reinstein, J., Menzel, A., Shoeman, R. L. & Schlichting, I., 2014, in : Journal of molecular biology. 426, 4, S. 853-868

  Publikation: Beitrag in einer Fachzeitschrift › Artikel

• Distinct chromophore-protein environments enable asymmetric activation of a bacteriophytochrome activated diguanylate cyclase

  Buhrke, D., Gourinchas, G., Müller, M., Michael, N., Hildebrandt, P. & Winkler, A., 10 Jan 2020, in : The Journal of Biological Chemistry. 295, 2, S. 539-551 13 S.

  Publikation: Beitrag in einer Fachzeitschrift › Artikel

  Open Access

  • Chromophores
  • Chemical activation
  • Light
  • Signal transduction
  • Proteins

• Hexicon 2: Automated Processing of Hydrogen-Deuterium Exchange Mass Spectrometry Data with Improved Deuteration Distribution Estimation

  Lindner, R., Lou, X., Reinstein, J., Shoeman, R. L., Hamprecht, F. A. & Winkler, A., 2014, in : Journal of the American Society for Mass Spectrometry. 25, 6, S. 1018-1028

  Publikation: Beitrag in einer Fachzeitschrift › Artikel

• Long-Range Allosteric Signaling in Red Light-Regulated Diguanylyl Cyclases

  Gourinchas, G. S., Etzl, S., Göbl, C., Vide, U., Madl, T. & Winkler, A., 3 Mär 2017, in : Science Advances. 3, 3, e1602498.

  Publikation: Beitrag in einer Fachzeitschrift › Artikel

  Open Access

  • red light
  • sensors (equipment)
  • guanosine
  • cell communication
  • phytochrome

• LOVTRAP: an optogenetic system for photoinduced protein dissociation

  Wang, H., Vilela, M., Winkler, A., Tarnawski, M., Schlichting, I., Yumerefendi, H., Kuhlman, B., Liu, R., Danuser, G. & Hahn, K. M., 2016, in : Nature methods. 13, S. 755-758

  Publikation: Beitrag in einer Fachzeitschrift › Artikel

  • Optogenetics
  • rac1 GTP-Binding Protein
  • Proteins
  • Staphylococcal Protein A
  • Phosphatidylinositol 3-Kinases

• Multi-PAS domain-mediated protein oligomerization of PpsR from Rhodobacter sphaeroides

  Heintz, U., Meinhart, A. & Winkler, A., 2014, in : Acta Crystallographica / D. 70, 3, S. 863-876

  Publikation: Beitrag in einer Fachzeitschrift › Artikel

• Oxidation of the FAD cofactor to the 8-formyl-derivative in human electron-transferring flavoprotein

  Augustin, P. A., Toplak, M., Fuchs, A. K., Gerstmann, E., Prassl, R. & Winkler, A., 4 Jan 2018, in : The Journal of Biological Chemistry. 293, 8, S. 2829-2840 21 S.

  Publikation: Beitrag in einer Fachzeitschrift › Artikel

• Photoactivation Mechanism of a Bacterial Light-Regulated Adenylyl Cyclase

  Lindner, R., Hartmann, E., Tarnawski, M., Winkler, A., Frey, D., Reinstein, J., Meinhart, A. & Schlichting, I., 5 Mai 2017, in : Journal of molecular biology. 429, 9, S. 1336-1351 16 S.

  Publikation: Beitrag in einer Fachzeitschrift › Artikel

  • Adenylyl Cyclases
  • Light
  • Deuterium Exchange Measurement
  • Beggiatoa
  • Catalytic Domain

• Rapid access to glycopeptide antibiotic precursor peptides coupled with cytochrome P450-mediated catalysis: towards a biomimetic synthesis of glycopeptide antibiotics

  Brieke, C., Kratzig, V., Haslinger, K., Winkler, A. & Cryle, M. J., 2015, in : Organic & biomolecular chemistry. 13, 7, S. 2012-2021

  Publikation: Beitrag in einer Fachzeitschrift › Artikel

• Rescuing DNA repair activity by rewiring the H-atom transfer pathway in the radical SAM enzyme, spore photoproduct lyase

  Benjdia, A., Heil, K., Winkler, A., Carell, T. & Schlichting, I., 2014, in : Chemical Communications. 50, S. 14201-14204

  Publikation: Beitrag in einer Fachzeitschrift › Artikel

• Structural and biochemical properties of LuxF from Photobacterium leiognathi

  Bergner, T., Tabib, C., Winkler, A., Stipsits, S., Kayer, H., Lee, J., Mayhew, S., Malthouse, J., Müller, F., Gruber, K. & Macheroux, P., 2015, in : Biochimica et Biophysica Acta. 1854, 10, S. 1466-1475

  Publikation: Beitrag in einer Fachzeitschrift › Artikel

• Structural Details of Light Activation of the LOV2-based Photoswitch PA-Rac1

  Winkler, A., Barends, T. R. M., Udvarhelyi, A., Lenherr-Frey, D., Lomb, L., Menzel, A. & Schlichting, I., 2015, in : ACS Chemical Biology. 10, S. 502-509

  Publikation: Beitrag in einer Fachzeitschrift › Artikel

• Structure-guided design and functional characterization of an artificial red light-regulated guanylate/adenylate cyclase for optogenetic applications

  Etzl, S., Lindner, R., Nelson, M. D. & Winkler, A., 8 Jun 2018, in : The Journal of Biological Chemistry. 293, 23, S. 9078-9089 12 S.

  Publikation: Beitrag in einer Fachzeitschrift › Artikel

  Open Access

  • Optogenetics
  • Guanylate Cyclase
  • Phytochrome
  • Adenylyl Cyclases
  • Light

• The single berberine bridge enzyme homolog of Physcomitrella patens is a cellobiose oxidase

  Toplak, M., Wiedemann, G., Ulićević, J., Daniel, B., Hoernstein, S. N. W., Kothe, J., Niederhauser, J., Reski, R., Winkler, A. & Macheroux, P., Mai 2018, in : The FEBS journal. 285, 10, S. 1923-1943 21 S.

  Publikation: Beitrag in einer Fachzeitschrift › Artikel

  • Biosynthesis
  • Alkaloids
  • Cellulose
  • Eschscholzia
  • Genes
• Poster

  Asymmetric structural rearrangements involved in light activation of a dimeric red light photoreceptor.

  Gourinchas, G. & Winkler, A., 2018, (Angenommen/In Druck).

  Publikation: Konferenzbeitrag › Poster

• Characterization of longe-range signal transduction in red-light activated diguanylyl cyclases

  Gourinchas, G. S., Etzl, S. & Winkler, A., 27 Jun 2016.

  Publikation: Konferenzbeitrag › Poster

  • Phytochrome
  • Signal Transduction
  • Light
  • Optogenetics
  • Biliverdine

• Exploring molecular mechanisms of signal transduction in light-regulated cyclases

  Etzl, S. & Winkler, A., 7 Jul 2016.

  Publikation: Konferenzbeitrag › Poster

• Exploring molecular mechanisms of signal transduction in light-regulated cyclases

  Etzl, S. & Winkler, A., 24 Jan 2016.

  Publikation: Konferenzbeitrag › Poster

• Exploring molecular mechanisms of signal transduction in light-regulated cyclases

  Etzl, S. & Winkler, A., 29 Sep 2016.

  Publikation: Konferenzbeitrag › Poster

• Exploring molecular mechanisms of signal transduction on light-regulated cyclases

  Etzl, S. & Winkler, A., 13 Sep 2016.

  Publikation: Konferenzbeitrag › Poster

• Functional cross talk of sensor and effector modules in red light activated diguanylyl cyclases

  Gourinchas, G., Winkler, A. & Vide, U., 2017, (In Vorbereitung).

  Publikation: Konferenzbeitrag › Poster

• Long-range allosteric regulation of GTP turnover in red-light modulated diguanylyl cyclases

  Gourinchas, G. S., Etzl, S. & Winkler, A., 3 Feb 2017, (Angenommen/In Druck).

  Publikation: Konferenzbeitrag › Poster

• Molecular mechanisms of red-light regulation in phytochrome linked adenylate/guanylate cyclases

  Etzl, S., Nelson, M. & Winkler, A., 7 Mär 2018.

  Publikation: Konferenzbeitrag › Poster

• Phytochrome-Activated Diguanylyl Cyclases: The Functional Relevance of Asymmetry

  Böhm, C., Balasso, M., Todorovic, N., Gourinchas, G. & Winkler, A., 6 Feb 2020.

  Publikation: Konferenzbeitrag › Poster

  • Phytochrome
  • Chemical activation
  • Biliverdine
  • Guanosine Triphosphate
  • Lighting

• Rescuing the stability and activity of a cancer associated variant of human NQO1 by small molecular chaperones

  Strandback, E. S., Lienhart, W-D., Hromic-Jahjefendic, A., Högler, A., Winkler, A., Zangger, K., Dandachi, N., Heitzer, E., Bourgeois, B., Madl, T., Breinbauer, R., Gruber, K. & Macheroux, P., 2017.

  Publikation: Konferenzbeitrag › Poster

• Rescuing the stability and activity of a cancer associated variant of human NQO1 by small molecular chaperones

  Strandback, E. S., Lienhart, W-D., Hromic-Jahjefendic, A., Högler, A., Winkler, A., Zangger, K., Dandachi, N., Heitzer, E., Bourgeois, B., Madl, T., Breinbauer, R., Gruber, K. & Macheroux, P., 2017.

  Publikation: Konferenzbeitrag › Poster

• Role of a conserved active site histidine in berberine bridge enzyme

  Wallner, S., Hromic, A., Steiner, B., Daniel, B., Winkler, A., Gruber, K. & Macheroux, P., 2012.

  Publikation: Konferenzbeitrag › Poster

• Stabilization of a cancer associated variant of human NQO1 by the use of small-molecular chaperones

  Strandback, E. S., Lienhart, W-D., Hromic-Jahjefendic, A., Högler, A., Waltenstorfer, D., Winkler, A., Zangger, K., Dandachi, N., Heitzer, E., Bourgeois, B., Madl, T., Breinbauer, R., Gruber, K. & Macheroux, P., 2017.

  Publikation: Konferenzbeitrag › Poster

• The origin of the berberine bridge enzyme-like protein family in plants

  Toplak, M., Wiedemann, G., Ulicevic, J., Daniel, B., Hoernstein, S., Kothe, J., Reski, R., Winkler, A. & Macheroux, P., Jul 2017.

  Publikation: Konferenzbeitrag › Poster
• Review eines Fachbereichs (Review article)

  Molecular Mechanisms of Bacterial Bioluminescence

  Brodl, E., Winkler, A. & Macheroux, P., 2018, in : Computational and Structural Biotechnology Journal. 16, S. 551 564 S.

  Publikation: Beitrag in einer Fachzeitschrift › Review eines Fachbereichs (Review article)

  Open Access

• The family of berberine bridge enzyme-like enzymes: A treasure-trove of oxidative reactions: A treasure-trove of oxidative reactions

  Daniel, B., Konrad, B., Toplak, M., Lahham, M., Messenlehner, J., Winkler, A. & Macheroux, P., 15 Okt 2017, in : Archives of Biochemistry and Biophysics. 632, S. 88-103 16 S.

  Publikation: Beitrag in einer Fachzeitschrift › Review eines Fachbereichs (Review article)

  • Flavin-Adenine Dinucleotide
  • Eschscholzia
  • Enzymes
  • Flavin Mononucleotide
  • Riboflavin