In vivo Assessment of Thermogenesis in Human Skeletal Muscle

The focus of this project is to assess local thermogenesis in skeletal muscle and to characterize muscle thermogenic regulation by employing state-of-the-art techniques as this particular tissue bed plays a critical role in whole body fuel metabolism and is thought to play a key role in the pathophysiology of obesity and insulin resistance. It is our aim to apply the unique combination of on-line measurement of pO2, pCO2, pH and temperature in muscle ICF and techniques for assessment of lipolysis, muscle sympathetic nervous activity, and oxidative fuel metabolism to investigate thermogenesis in skeletal muscle.