GEN-AU GOLD 3 (Genomics of Lipid-associated Disorders): C4: Exploring the lipolytic proteome. Phospholipases

  • Zenzmaier, Elfriede (Teilnehmer (Co-Investigator))
  • Lehsl, Annemarie, (Teilnehmer (Co-Investigator))
  • Morak, Maria, (Teilnehmer (Co-Investigator))
  • Schicher, Maximilian, (Teilnehmer (Co-Investigator))
  • Hermetter, Albin (Projektleiter (Principal Investigator))

Projekt: Foschungsprojekt

Projektdetails

Beschreibung

The component aims at identifying the subset of glycerophospholipid hydrolases in mammalian cell proteomes. For this purpose taylor-made phospholipids will be developed as suicide inhibitors, photoactivatable probes and substrates for the selective detection and functional characterization of the active target enzymes in cultured animal cells and tissues. These novel molecular tools will be used to identify yet unknown phospholipases that escaped detection by conventional methods so far.
StatusAbschlussdatum
Tatsächlicher Beginn/ -es Ende1/02/0931/01/12

Publikationen

  • 11 Artikel
  • 2 (Altdaten) Vortrag oder Präsentation
  • 1 Poster

Adipose triglyceride lipase (ATGL) and hormone sensitive lipase (HSL) deficiences affect expression of lipolytic activities in mouse adipose tissues

Morak, M., Schmidinger, H., Riesenhuber, G., Rechberger G, N. V., Kollroser M, N. V., Haemmerle, G., Zechner, R., Kronenberg, F. & Hermetter, A., 2012, in : Molecular & cellular proteomics. 11, 12, S. 1777-1789

Publikation: Beitrag in einer FachzeitschriftArtikel

Adipose triglyceride lipase (ATGL) and hormone-sensitive lipase (HSL) deficiencies affect expression of lipolytic activities in mouse adipose tissues

Morak, M., Schmidinger, H., Riesenhuber, G., Rechberger GN, N. V., Kollroser M, N. V., Haemmerle G, N. V., Zechner R, N. V., Kronenberg F, N. V. & Hermetter, A., 2012, in : Molecular & cellular proteomics. 11, 12, S. 1777-1789

Publikation: Beitrag in einer FachzeitschriftArtikel

Catalytic residues and a predicted structure of tetrahydrobiopterin-dependent alkylglcerol monooxygenase

Watschinger, K., Fuchs, JE., Yarov-Yarovoy, V., Keller, MA., Golderer, G., Hermetter, A., Werner-Felmayer, G., Hulo, N. & Werner, ER., 2012, in : Biochemical Journal. 443, 1, S. 279-286

Publikation: Beitrag in einer FachzeitschriftArtikel