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Mario Klimacek

Priv.-Doz. Dipl.-Ing. Dr.nat.techn.

20022021
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Forschungsoutput 2002 2019

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2015

Identification of novel metabolic interactions controlling carbon flux from xylose to ethanol in natural and recombinant yeasts

Trausinger, G., Gruber, C., Krahulec, S., Magnes, C., Nidetzky, B. & Klimacek, M., 2015, in : Biotechnology for Biofuels . 8:157, S. 1-13

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

Speeding up the product release: a second-sphere contribution from Tyr191 to the reactivity of l-lactate oxidase revealed in crystallographic and kinetic studies of site-directed variants.

Stoisser, T., Klimacek, M., Wilson, D. K. & Nidetzky, B., 2015, in : The FEBS journal. 282, 21, S. 4130-4140

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

2014

Process intensification through microbial strain evolution: mixed glucose-xylose fermentation in wheat straw hydrolyzates by three generations of recombinant Saccharomyces cerevisiae

Novy, V., Krahulec, S., Wegleiter, M., Müller, G., Longus, K., Klimacek, M. & Nidetzky, B., 2014, in : Biotechnology for Biofuels . 7, 49, S. 1-12

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

Stepwise metabolic adaption from pure metabolization to balanced anaerobic growth on xylose explored for recombinant Saccharomyces cerevisiae

Klimacek, M., Kirl, E., Krahulec, S., Longus, K., Novy, V. & Nidetzky, B., 2014, in : Microbial cell factories . 13, 37, S. 1-12

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

2013

Co-fermentation of hexose and pentose sugars in a spent sulfite liquor matrix with genetically modified Saccharomyces cerevisiae

Novy, V., Krahulec, S., Longus, K., Klimacek, M. & Nidetzky, B., 2013, in : Bioresource Technology. 130, S. 439-448

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

Structural and kinetic evidence that the catalytic reaction of human UDP-glucose 6-dehydrogenase involves covalent thiohemiacetal and thioester enzyme intermediates

Egger, S., Chaikuad, A., Klimacek, M., Kavanagh, K. L., Oppermann, U. & Nidetzky, B., 2012, in : The Journal of Biological Chemistry. 287, S. 2119-2129

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

Limitations in xylose-fermenting Saccharomyces cerevisiae, made evident through comprehensive metabolite profiling and thermodynamic analysis

Klimacek, M., Krahulec, S., Sauer, U. & Nidetzky, B., 2010, in : Applied and Environmental Microbiology. S. 7566-7574

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

2009

Engineering of a matched pair of xylose reductase and xylitol dehydrogenase for xylose fermentation by Saccharomyces cerevisiae

Krahulec, S., Klimacek, M. & Nidetzky, B., 2009, in : Biotechnology Journal. 4, S. 684-694

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

Novel Chemo-Enzymatic Mimic of Hydrogen Peroxide-Forming NAD(P)H Oxidase for Efficient Regeneration of NAD+ and NADP+

Pival, S., Klimacek, M. & Nidetzky, B., 2008, in : Advanced Synthesis & Catalysis. 350, 14-15, S. 2305-2312

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

Structure-guided engineering of the coenzyme specificity of Pseudomonas fluorescens mannitol 2-dehydrogenase to enable efficient utilization of NAD(H) and NADP(H)

Bubner, P., Klimacek, M. & Nidetzky, B., 2008, in : FEBS letters. 582, 2, S. 233-237

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

Role of Phe-114 in substrate specificity of Candida tenuis xylose reductase (AKR2B5)

Klimacek, M., Kratzer, R., Szekely, M. & Nidetzky, B., 2007, in : Biocatalysis and Biotransformation. 25, 2-4, S. 194-201

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

2006

Optimization of an innovative hollow-fiber process to produce lactose-reduced skim milk.

Neuhaus, W., Novalin, S., Klimacek, M., Splechtna, B., Petzelbauer, I., Szivak, A. & Kulbe, K. D., 2006, in : Applied Biochemistry and Biotechnology / A. S. 1-14

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

2003

On the role of Bronsted catalysis in Pseudomonas fluorescens mannitol 2-dehydrogenase.

Klimacek, M., Kavanagh, K. L., Wilson, D. K. & Nidetzky, B., 2003, in : Biochemical Journal. 375, S. 141-149

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

The structure of xylose reductase bound to NAD+ and the basis for single and dual co-substrate specificity in family 2 aldo-keto reductases.

Kavanagh, K. L., Klimacek, M., Nidetzky, B. & Wilson, D. K., 2003, in : Biochemical Journal. 373, S. 319-326

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

The xylose reductase (AKR2B5) structure: homology and divergence from other aldo-keto reductases and opportunities for protein engineering.

Wilson, D., Kavanagh, K., Klimacek, M. & Nidetzky, B., 2003, in : Chemico-Biological Interactions. 143-144, S. 515-521

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung