Margit Winkler

Priv.-Doz. Dipl.-Ing. Dr.techn.

19992023
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Forschungsoutput 2001 2019

2019

3-Hydroxytyrosol: A whole cell mediated Bioreduction using a type IV Carboxylate Reductase

Horvat, M. & Winkler, M., 9 Jul 2019.

Publikation: KonferenzbeitragPosterForschung

A cell-free in vitro reduction of carboxylate to aldehyde

Schwarz, A., Strohmeier, G., Eiteljörg, I., Kohrt, J., Howard, R. & Winkler, M., Nov 2019.

Publikation: KonferenzbeitragPosterForschung

A functionally-distinct carboxylic acid reductase (PcCAR4) unearthed from a repertoire of type IV CARs in the white-rot fungus Pycnoporus cinnabarinus

Ling, J. G., Mansor, M. H., Murad, M. A., Khalid, R. M., Quay, D. H-X., Winkler, M. & Bakar, F. D. A., 2019, in : Journal of Biotechnology. 2020, 307, S. 55-62

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

Pycnoporus
Fungi
Carboxylic acids
Genes
Enzymes

A Multi-Enzyme System for the In vitro Reduction of Carboxylic Acids to Aldehydes

Strohmeier, G., Schwarz, A., Eiteljörg, I., Kohrt, J., Howard, R. & Winkler, M., Jul 2019.

Publikation: KonferenzbeitragPosterForschung

Capsaicin Metabolite Synthesis by Fungal Cytochrome P450

Willim, M., Bachler, T., Schweda, B., Migglautsch, A. K., Glieder, A., Breinbauer, R. & Winkler, M., 14 Feb 2019.

Publikation: KonferenzbeitragPosterForschung

Carboxylic acid reductases in the white-rot fungus Pycnoporus cinnnabarinus

Ling, J. G., Mansor, M. H., Murad, M. A., Khalid, R. M., Quay, D. H-X., Eiteljörg, I., Stolterfoht, H., Winkler, M. & Bakar, F. D. A., Nov 2019.

Publikation: KonferenzbeitragPosterForschung

Characterization of carboxylate reductases (CARs) for the reduction of aromatic carboxylic acids with integrated in vitro cofactor recycling

Weber, D., Patsch, D., Winkler, M., Turner, N. J. & Rother, D., Nov 2019.

Publikation: KonferenzbeitragPosterForschung

Characterization of Type IV Carboxylate Reductases (CARs) for Whole Cell-Mediated Preparation of 3-Hydroxytyrosol

Horvat, M., Fritsche, S., Kourist, R. & Winkler, M., 19 Mär 2019, in : ChemCatChem. S. 4171-4181

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

carboxylates
Oxidoreductases
preparation
cells
aldehydes

Chimeric Carboxylate Reductases

Stolterfoht, H., Gradischnig, D. & Winkler, M., Nov 2019.

Publikation: KonferenzbeitragPosterForschung

Co-factor demand and regeneration in the enzymatic one-step reduction of carboxylates to aldehydes in cell-free systems

Strohmeier, G., Schwarz, A., Andexer, J. N. & Winkler, M., 28 Okt 2019, (Angenommen/In Druck) in : Journal of Biotechnology. 14 S.

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

Cell-Free System
Aldehydes
Regeneration
Adenosine Triphosphate
Sinorhizobium meliloti

Comparison of two new and a known Type IV fungal Carboxylate reductase

Horvat, M., Fritsche, S. & Winkler, M., Nov 2019.

Publikation: KonferenzbeitragPosterForschung

Cytochrome P450 mediated hydroxylation of ibuprofen using Pichia pastoris as biocatalyst

Rinnofner, C., Kerschbaumer, B., Weber, H., Glieder, A. & Winkler, M., Nov 2019.

Publikation: KonferenzbeitragPosterForschung

Cytochrome P450 mediated hydroxylation of ibuprofen using Pichia pastoris as biocatalyst

Rinnofner, C., Kerschbaumer, B., Weber, H., Glieder, A. & Winkler, M., Apr 2019.

Publikation: KonferenzbeitragPosterForschung

Cytochrome P450 mediated hydroxylation of ibuprofen using Pichia pastoris as biocatalyst

Rinnofner, C., Kerschbaumer, B., Weber, H., Glieder, A. & Winkler, M., 2019, in : Biocatalysis and Agricultural Biotechnology. 17, S. 525-528 4 S.

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

Open Access
ibuprofen
Hydroxylation
Pichia pastoris
Biocatalysts
Pichia

Discovery of carboxylic acid reductase (CAR) from Thermothelomyces thermophilus and its evaluation for vanillin synthesis

Horvat, M., Fiume, G., Fritsche, S. & Winkler, M., 12 Aug 2019, in : Journal of Biotechnology. 304, S. 44-51

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

Carboxylic acids
Substrates
Vanillic Acid
Eugenol
Acids

Enzymatic One-Step Reduction of Carboxylates to Aldehydes with Cell-Free Regeneration of ATP and NADPH

Strohmeier, G., Eiteljörg, I., Schwarz, A. & Winkler, M., 26 Apr 2019, in : Chemistry - a European Journal. 25, 24, S. 6119-6123 5 S.

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

Open Access
Adenosinetriphosphate
Aldehydes
NADP
Carboxylic Acids
Adenosine Triphosphate

Enzyme-catalyzed synthesis of amides from nitriles

Glänzer, M., Grill, B., Schwab, H., Pogorevcnik, U., Reicher, K., Donsbach, K., Pienaar, D. & Winkler, M., Sep 2019.

Publikation: KonferenzbeitragPosterForschung

Exploring the Biocatalytic Potential of a Self‐Sufficient Cytochrome P450 from Thermothelomyces thermophila

Fürst, M. J. L. J., Kerschbaumer, B., Rinnofner, C., Migglautsch, A. K., Winkler, M. & Fraaije, M. W., 2019, in : Advanced Synthesis & Catalysis. 361, 11, S. 2487-2496

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

Open Access

Form follows function: Structure of the carboxylate reductase from Neurospora crassa (NcCAR)

Daniel, B., Pavkov-Keller, T., Leithold, M., Stolterfoht, H., Winkler, M. & Gruber, K., Nov 2019.

Publikation: KonferenzbeitragPosterForschung

Human drug metabolite synthesis catalysed by recombinant P450 enzymes

Glieder, A., Weninger, A., Schmid, C., Rinnofner, C., Winkler, M., Müller, M., Schürmann, M., Woodley, J., Valero, F., Garcia-Ortega, X., Fürst, M. J. L. J. & Fraaije, M. W., Jun 2019.

Publikation: KonferenzbeitragAbstractForschung

Nitrile hydratasees for synthesis of amides from nitriles

Grill, B., Schwab, H., Pogorevcnik, U., Glänzer, M., Reicher, K., Donsbach, K. & Winkler, M., Nov 2019.

Publikation: KonferenzbeitragPosterForschung

Optimizing the heterologous expression of the carboxylic acid reductase from Nocardia otitidiscavium for the reduction of aromatic acids

Weber, D., Patsch, D., Winkler, M., Turner, N. & Rother, D., 9 Jul 2019.

Publikation: KonferenzbeitragPosterForschung

Random Mutagenesis-Driven Improvement of Carboxylate Reductase Activity Using an Amino Benzamidoxime-Mediated High-Throughput Assay

Schwendenwein, D., Ressmann, A. K., Dörr, M., Höhne, M., Mihovilovic, M. D., Bornscheuer, U. T., Rudroff, F. & Winkler, M., 6 Jun 2019, in : Advanced Synthesis & Catalysis. 361, 11, S. 2544-2549 6 S.

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

Mutagenesis
Carboxylic acids
Assays
Oxidoreductases
Throughput

Random mutagenesis of carboxylate reductase enabled by a substrate independent HT-assay

Rudroff, F., Winkler, M., Schwendenwein, D., Ressmann, A. K., Mihovilovic, M. D., Bornscheuer, U. T. & Dörr, M., Jul 2019.

Publikation: KonferenzbeitragPosterForschung

Recombinant lipoxygenases (LOX) and hydroperoxide lyases (HPL) for the synthesis of green leaf volatiles

Stolterfoht, H., Rinnofner, C., Winkler, M. & Pichler, H., 8 Okt 2019, (Angenommen/In Druck) in : Journal of agricultural and food chemistry. 59 S.

Publikation: Beitrag in einer FachzeitschriftReview eines Fachbereichs (Review article)ForschungBegutachtung

Lipoxygenases
lyases
hydroperoxides
lipoxygenase
synthesis

Recombinant lipoxygenases and hydroperoxide lyases for the synthesis of green leaf volatiles

Stolterfoht, H., Rinnofner, C., Winkler, M. & Pichler, H., 2019, (Angenommen/In Druck) in : Journal of agricultural and food chemistry.

Publikation: Beitrag in einer FachzeitschriftReview eines Fachbereichs (Review article)ForschungBegutachtung

Structure elucidation of the carboxylate reductase from Neurospora crassa (NcCAR)

Daniel, B., Pavkov-Keller, T., Leithold, M., Gruber, K., Stolterfoht, H. & Winkler, M., 9 Jul 2019.

Publikation: KonferenzbeitragPosterForschung

Substrate-Independent High-Throughput Assay for the Quantification of Aldehydes

Ressmann, A. K., Schwendenwein, D., Leonhartsberger, S., Mihovilovic, M. D., Bornscheuer, U. T., Winkler, M. & Rudroff, F., 6 Jun 2019, in : Advanced Synthesis & Catalysis. 361, 11, S. 2538-2543 6 S.

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

Aldehydes
Carboxylic acids
Assays
Throughput
Substrates

Towards a new panel of nitrile hydratases

Grill, B., Schwab, H., Glänzer, M., Steinkellner, G., Strohmeier, G., Pogorevcnik, U., Reicher, K., Gruber, K., Donsbach, K. & Winkler, M., 26 Jun 2019.

Publikation: KonferenzbeitragPosterForschung

2018

Aliphatic hydroxylation and epoxidation of capsaicin by Cytochrome P450 CYP505X

Migglautsch, A. K., Willim, M., Schweda, B., Glieder, A., Breinbauer, R. & Winkler, M., 31 Aug 2018, in : Tetrahedron. 74, S. 6199-6204

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

A novel assay for the detection of carboxylic acid reductase (CAR) activity in whole cells

Schwendenwein, D., Ressmann, A. K., Mihovilovic, M. D., Bornscheuer, U. T., Dörr, M., Rudroff, F. & Winkler, M., 27 Aug 2018.

Publikation: KonferenzbeitragPosterForschung

Carboxylic acid reductase enzymes (CARs)

Winkler, M., 2018, in : Current opinion in chemical biology. 43, S. 23-29

Publikation: Beitrag in einer FachzeitschriftReview eines Fachbereichs (Review article)ForschungBegutachtung

Combinatorial optimization strategies to increase Human P450 catalytic Activity in whole cell

Weninger, A., Alkofer, A., Schmid, C., Bitter, J., Volpini de Maestri, A., Pranjic, M., Winkler, M. & Glieder, A., Sep 2018.

Publikation: KonferenzbeitragPosterForschung

Discovery and characterization of the tubercidin biosynthetic pathway from Streptomyces tubercidicus NBRC 13090

Liu, Y., Gong, R., Liu, X., Zhang, P., Zhang, Q., Cai, Y-S., Deng, Z., Winkler, M., Wu, J. & Chen, W., 2018, in : Microbial cell factories . 17, 10 S., 131.

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

Open Access

Fatty Alcohols: enzymatically from Free fatty Acids

Horvat, M., Zabielska, J., Kourist, R. & Winkler, M., 3 Jul 2018.

Publikation: KonferenzbeitragPosterForschung

Fragrance synthesis via a chemo- & multi enzyme cascade

Rudroff, F., Winkler, M., Entner, M., Schwendenwein, D., Ressmann, A. K. & Mihovilovic, M. D., Jul 2018.

Publikation: KonferenzbeitragPosterForschung

Humane Enzyme für die Organische Synthese

Winkler, M., Geier, M., Hanlon, S. P., Nidetzky, B. & Glieder, A., 2018, in : Angewandte Chemie. 130, S. 13592-13610

Publikation: Beitrag in einer FachzeitschriftReview eines Fachbereichs (Review article)ForschungBegutachtung

Human Enzymes for Organic Synthesis

Winkler, M., Geier, M., Hanlon, S. P., Nidetzky, B. & Glieder, A., 2018, in : Angewandte Chemie / International Edition . 57, 41, S. 13406-13423 18 S.

Publikation: Beitrag in einer FachzeitschriftReview eines Fachbereichs (Review article)ForschungBegutachtung

Enzymes
Pharmaceutical Preparations
Xenobiotics
Metabolites
Metabolism

Hybrid CARs (carboxylate reductases)

Stolterfoht, H., Gradischnig, D. & Winkler, M., 10 Okt 2018.

Publikation: KonferenzbeitragPosterForschung

Identification of key residues for enzymatic carboxylate reduction

Stolterfoht, H., Steinkellner, G., Schwendenwein, D., Pavkov-Keller, T., Gruber, K. & Winkler, M., 12 Feb 2018, in : Frontiers in Microbiology . 9, 250.

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

Production of Hydroxynitrile Lyase from Davallia tyermannii (DtHNL) in Komagataella phaffii and Its Immobilization as a CLEA to Generate a Robust Biocatalyst

Lanfranchi, E., Grill, B., Raghoebar, Z., Van Pelt, S., Sheldon, R. A., Steiner, K., Glieder, A. & Winkler, M., 2018, in : ChemBioChem. 19, 4, S. 312-316 10.1002/cbic.201700419.

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

mandelonitrile lyase
Immobilization
Enzymes
Ferns
Agrochemicals

Screening for new plant hydroxynitrile lyases

Winkler, M., Schwendenwein, D., Archer, R. & Rumbold, K., 2 Jul 2018.

Publikation: KonferenzbeitragPosterForschung

Small molecule Aldehydes from Carboxylic acid bioreduction

Horvat, M., Fiume, G., Stolterfoht, H., Schwendenwein, D., Schmidt, S. & Winkler, M., 9 Feb 2018.

Publikation: KonferenzbeitragPosterForschung

Substrate independent high-throughput assay for the quantitative assessment of carboxylic acid reductase activity in living cells

Ressmann, A. K., Schwendenwein, D., Leonhartsberger, S., Dörr, M., Mihovilovic, M. D., Bornscheuer, U. T., Winkler, M. & Rudroff, F., 2018.

Publikation: KonferenzbeitragAbstractForschung

Synthesis of fragrance aldehydes by the combination of chemo and biocatalysis in microbial cell factories

Rudroff, F., Ressmann, A. K., Schwendenwein, D., Leonhartsberger, S., Dörr, M., Mihovilovic, M. D., Bornscheuer, U. T. & Winkler, M., 2018.

Publikation: KonferenzbeitragAbstractForschung

The ABAO assay, a new tool for Carboxylic Acid Reductase engineering

Rudroff, F., Winkler, M., Schwendenwein, D., Ressmann, A. K., Mihovilovic, M. D., Bornscheuer, U. T. & Dörr, M., Jul 2018.

Publikation: KonferenzbeitragPosterForschung

2017

Carboxylic Acid Reductase mediated Biotransformations

Schwendenwein, D., Fiume, G., Pichler, H. & Winkler, M., 11 Jul 2017.

Publikation: KonferenzbeitragPosterForschung