Research Center Pharmaceutical Engineering GmbH (RCPE) (98888)

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    Inffeldgasse 13 Graz

    Österreich

Forschungsoutput 1991 2020

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2020

Feeding of particle-based materials in continuous solid dosage manufacturing: a material science perspective

Hsiao, W-K., Hörmann, T. R., Toson, P., Paudel, A., Ghiotti, P., Stauffer, F., Bauer, F., Lakio, S., Behrend, O., Maurer, R., Holman, J. & Khinast, J., Jan 2020, (Angenommen/In Druck) in : Drug Discovery Today.

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

Materials science
Drug products
Processing
Industry

Model predictive control for continuous pharmaceutical feeding blending units

Celikovic, S., Kirchengast, M., Rehrl, J., Kruisz, J., Sacher, S., Khinast, J. & Horn, M., 2020, in : Chemical Engineering Research and Design / A. 2020, 154, S. 101-114 14 S.

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

Open Access

Powder flow and mixing in different tablet press feed frames

Siegmann, E., Forgber, T., Toson, P., Martinetz, M. C., Kureck, H., Brinz, T., Manz, S., Grass, T. & Khinast, J., 1 Jan 2020, (Angenommen/In Druck) in : Advanced powder technology.

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

Powders
Tablets
Compaction
Residence time distribution
Finite difference method

Towards a novel continuous HME-Tableting line: Process development and control concept

Sacher, S., Celikovic, S., Rehrl, J., Poms, J., Kirchengast, M., Kruisz, J., Sipek, M., Salar-Behzadi, S., Berger, H., Stark, G., Horn, M. & Khinast, J. G., 15 Jan 2020, in : European Journal of Pharmaceutical Sciences. 142

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

2019

An evaluation of the gliding performance of solid oral dosage form film coatings using an artificial mucous layer

Drumond, N. & Stegemann, S., 1 Mai 2019, in : Colloids and Surfaces B: Biointerfaces. 177, S. 235-241 7 S.

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

gliding
Dosage Forms
Polymers
coatings
Polymer films

A novel in silico scale-up approach for hot melt extrusion processes

Matic, J., Witschnigg, A., Zagler, M., Eder, S. & Khinast, J., 31 Aug 2019, in : Chemical Engineering Science. 204, S. 257-269

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

A numerical investigation into the effect of angular particle shape on blast furnace burden topography and percolation using a GPU solved discrete element model

Govender, N., Wilke, D. N., Wu, C-Y., Tuzun, U. & Kureck, H. G., 31 Aug 2019, in : Chemical Engineering Science. S. 9-26 18 S.

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

Polydispersity
Blast furnaces
Topography
Coke
Ores

At-line validation of optical coherence tomography as in-line/at-line coating thickness measurement method

Wolfgang, M., Peter, A., Wahl, P., Markl, D., Zeitler, J. A. & Khinast, J. G., 15 Dez 2019, in : International Journal of Pharmaceutics. 572

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

Can we predict trends in tribo-charging of pharmaceutical materials from first principles?

Brunsteiner, M., Zellnitz, S., Pinto, J. T., Karrer, J. & Paudel, A., 1 Nov 2019, in : Powder Technology. 356, S. 892-898 7 S.

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

Ionization potential
Drug products
Pharmaceutical Preparations
Discrete Fourier transforms
Electronic structure

Computational Fluid Dynamics-Discrete Element Method Modeling of an Industrial-Scale Wurster Coater

Boehling, P., Khinast, J. G., Jajcevic, D., Davies, C., Carmody, A., Doshi, P., Ende, M. T. A. & Sarkar, A., Jan 2019, in : Journal of Pharmaceutical Sciences . 108, 1, S. 538-550

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

Ensuring Tablet Quality via Model-based Control of a Continuous Direct Compaction Process

Kirchengast, M., Celikovic, S., Rehrl, J., Sacher, S., Kruisz, J., Khinast, J. & Horn, M., 15 Aug 2019, in : International Journal of Pharmaceutics. 2019, 567, S. 1-9 9 S.

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

Computational fluid dynamics
Fires
X ray photoelectron spectroscopy
Momentum transfer
Drug products

Formulation and processability screening for the rational design of ethylene-vinyl acetate based intra-vaginal rings

Koutsamanis, I., Eder, S., Beretta, M., Witschnigg, A., Paudel, A., Nickisch, K., Friedrich, M., Eggenreich, K. & Roblegg, E., 10 Jun 2019, in : International Journal of Pharmaceutics. 564, S. 90-97 8 S.

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

Female Contraceptive Devices
Membranes
Polymers
Hormone Replacement Therapy
Silicones
Near-Infrared Spectroscopy
Optical Coherence Tomography
Tablets
Weights and Measures
Dosage Forms

Impact of drug particle shape on permeability and cellular uptake in the lung

Zellnitz, S., Zellnitz, L., Müller, M. T., Meindl, C., Schröttner, H. & Fröhlich, E., 1 Nov 2019, in : European Journal of Pharmaceutical Sciences. 139, 105065.

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

Albuterol
Permeability
Budesonide
Macrophages
Lung
Open Access
Particle Size
Linear Models
Pharmaceutical Preparations
Temperature

Industrial scale simulations of tablet coating using gpu based dem: A validation study

Kureck, H. G., Govender, N., Siegmann, E., Böhling, P., Radeke, C. & Khinast, J., 20 Jul 2019, in : Chemical Engineering Science. S. 462-480 19 S.

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

Tablets
Coatings
Computational methods
Finite difference method
Costs

Insights into DPI sensitivity to humidity: An integrated in-vitro-in-silico risk-assessment

Radivojev, S., Pinto, J. T., Fröhlich, E. & Paudel, A., 1 Aug 2019, in : Journal of Drug Delivery Science and Technology. 52, S. 803-817 15 S.

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

Dry Powder Inhalers
Humidity
Budesonide
Computer Simulation
Powders

Measurement of granule layer thickness in a spouted bed coating process via optical coherence tomography

Pietsch, S., Peter, A., Wahl, P., Khinast, J. & Heinrich, S., Nov 2019, in : Powder Technology. 356, S. 139-147

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

Measurement of residence time distributions and material tracking on three continuous manufacturing lines

Karttunen, A. P., Hörmann, T. R., De Leersnyder, F., Ketolainen, J., De Beer, T., Hsiao, W. K. & Korhonen, O., 30 Mai 2019, in : International Journal of Pharmaceutics. 563, S. 184-197 14 S.

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

Video Recording
Color
Pharmaceutical Preparations

Measuring bulk density variations in a moving powder bed via terahertz in-line sensing

Stranzinger, S., Faulhammer, E., Li, J., Dong, R., Khinast, J. G., Zeitler, J. A. & Markl, D., 15 Feb 2019, in : Powder Technology. 344, S. 152-160

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

Mechanistic modelling of fluid bed granulation, Part II: Eased process development via degree of wetness

Askarishahi, M., Salehi, M. S., Maus, M., Schröder, D., Slade, D. & Jajcevic, D., 15 Dez 2019, in : International Journal of Pharmaceutics. 572, 118836.

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

Temperature
Hot Temperature
Costs and Cost Analysis
Population

Model-based approach to the design of pharmaceutical roller-compaction processes

Toson, P., Lopes, D. G., Paus, R., Kumar, A., Geens, J., Stibale, S., Quodbach, J., Kleinebudde, P., Hsiao, W-K. & Khinast, J., Dez 2019, in : International Journal of Pharmaceutics: X. 1, 100005.

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

Open Access
Drug products
Compaction
Throughput
Design of experiments
Process design

Oxygen sensors for flow reactors-measuring dissolved oxygen in organic solvents

Sulzer, P., Lebl, R., Kappe, C. O. & Mayr, T., 1 Dez 2019, in : Reaction Chemistry and Engineering. 4, 12, S. 2081-2087 7 S.

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

Open Access
Oxygen sensors
Dissolved oxygen
Organic solvents
Sensors
Oxygen

Particle-level residence time data in a twin-screw feeder

Toson, P. & Khinast, J. G., Dez 2019, in : Data in Brief . 27, 104672

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

Performance Characterization of Static Mixers in Precipitating Environments

Kreimer, M., Zettl, M., Aigner, I., Mannschott, T., van der Wel, P., Khinast, J. G. & Krumme, M., Jul 2019, in : Organic process research & development. 23, 7, S. 1308-1320

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

Predicting capsule fill weight from in-situ powder density measurements using terahertz reflection technology

Stranzinger, S., Faulhammer, E., Li, J., Dong, R., Zeitler, J. A., Biserni, S., Calzolari, V., Khinast, J. G. & Markl, D., 1 Dez 2019, in : International Journal of Pharmaceutics: X. 1, 100004.

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

Open Access
Powders
Capsules
Technology
Weights and Measures
Specific Gravity

Predicting the formation of satellite droplets in inkjet printing

Planchette, C., Brenn, G., Marangon, F. & Hsiao, W. K., 2019, (Angenommen/In Druck) in : Physical Review Fluids. 2019

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

Pvp-h2o2 complex as a new stressor for the accelerated oxidation study of pharmaceutical solids

Modhave, D., Barrios, B. & Paudel, A., 1 Sep 2019, in : Pharmaceutics . 11, 9, 457.

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

Open Access
Excipients
Peroxides
Pharmaceutical Preparations
Hydrogen Peroxide
Povidone

Shedding light on coatings: Real-time monitoring of coating quality at industrial scale

Sacher, S., Wahl, P., Weissensteiner, M., Wolfgang, M., Pokhilchuk, Y., Looser, B., Thies, J., Raffa, A. & Khinast, J. G., 20 Jul 2019, in : International Journal of Pharmaceutics. 566, S. 57-66

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

Study of the capsule-filling dosator process via calibrated DEM simulations

Madlmeir, S., Loidolt, P. & Khinast, J. G., 15 Aug 2019, in : International Journal of Pharmaceutics. 567

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

TFM-based Full Physics Simulations of Mixing in Non-Cohesive Wet Fluidized Beds

Askarishahi, M., Salehi, M. & Radl, S., 12 Jun 2019, (Angenommen/In Druck) in : Industrial and Engineering Chemistry Research.

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

The need for new control strategies for particulate matter in parenterals

Poms, J., Sacher, S., Nixdorf, M., Dekner, M., Wallner-Mang, S., Janssen, I., Khinast, J. G. & Schennach, R., 3 Jul 2019, in : Pharmaceutical development and technology. 24, 6, S. 739-750 12 S.

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

Particulate Matter
Process Assessment (Health Care)
Risk Management
Patient Safety
Guidelines

Tribo-Charging Behaviour of Inhalable Mannitol Blendswith Salbutamol Sulphate

Zellnitz, S., Pinto, J., Brunsteiner, M., Schröttner, H., Khinast, J. & Paudel, A., 2019, in : Pharmaceutical research. 36, 6, S. 80 11 S., 36:80.

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

Two-Fluid-Model-Based Full Physics Simulations of Mixing in Noncohesive Wet Fluidized Beds

Askarishahi, M., Salehi, M. S. & Radl, S., 10 Jul 2019, in : Industrial and Engineering Chemistry Research. 58, 27, S. 12323-12346 24 S.

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

Fluidized beds
Physics
Drying
Fluids
Spraying
2018

A combined DEM & FEM approach for modelling roll compaction process

Mazor, A., Orefice, L., Michrafy, A., de Ryck, A. & Khinast, J. G., Sep 2018, in : Powder Technology. 337, S. 3-16 14 S.

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

Rolls (machine components)
Finite difference method
Compaction
Powders
Finite element method

Advances in experimental and mechanistic computational models to understand pulmonary exposure to inhaled drugs

Bäckman, P., Arora, S., Couet, W., Forbes, B., de Kruijf, W. & Paudel, A., 15 Feb 2018, in : European Journal of Pharmaceutical Sciences. 113, S. 41-52 11 S.

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

Inhalation Exposure
Computer Simulation
Lung
Pharmaceutical Preparations
Aerosols

A multivariate process monitoring strategy and control concept for a small-scale fermenter in a PAT environment

Besenhard, M. O., Scheibelhofer, O., François, K., Joksch, M. & Kavsek, B., 1 Okt 2018, in : Journal of Intelligent Manufacturing. 29, 7, S. 1501-1514 14 S.

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

Fermenters
Process monitoring
Process control
Fermentation
Yeast

Assessment of Dry Powder Inhaler Carrier Targeted Design: A Comparative Case Study of Diverse Anomeric Compositions and Physical Properties of Lactose

Pinto, J. T., Zellnitz, S., Guidi, T., Roblegg, E. & Paudel, A., 1 Jun 2018, in : Molecular pharmaceutics. 15, 7, S. 2827-2839

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

Dry Powder Inhalers
Lactose
Adhesives
Gas Lasers
Surface Properties

Characterization of the coating and tablet core roughness by means of 3D optical coherence tomography

Khinast, J., Markl, D., Wahl, P., Pichler, H. & Sacher, S., 2018, in : International Journal of Pharmaceutics. S. 459-466

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

Continuous Drying of Pharmaceutical Powders Using a Twin-Screw Extruder

Kreimer, M., Aigner, I., Lepek, D. & Khinast, J., 20 Jul 2018, in : Organic Process Research and Development. 22, 7, S. 813-823 11 S.

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

screws
Extruders
Powders
drying
Drying

Continuous-Flow In-Line Solvent-Swap Crystallization of Vitamin D3

Escriba-Gelonch, M., Hessel, V., Maier, M. C., Neira, M. F. & Gruber-Wölfler, H., 2018, in : Organic process research & development. 22, 2, S. 178-189

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

Open Access

Control of three different continuous pharmaceutical manufacturing processes: Use of soft sensors

Rehrl, J., Kartunnen, A-P., Nicolaï, N., Hörmann, T., Horn, M., Korhonnen, O., Nopens, I., de Beer, T. & Khinast, J., 30 Mai 2018, in : International Journal of Pharmaceutics. 543, 1-2, S. 60-72

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

Crystal Shape Modification via Cycles of Growth and Dissolution in a Tubular Crystallizer

Neugebauer, P., Besenhard, M., Peter, A., Gruber-Wölfler, H. & Khinast, J., 15 Jun 2018, in : Crystal Growth and Design. 18, 8, S. 4403-4415

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

Density fluctuations in amorphous pharmaceutical solids. Can SAXS help to predict stability?

Laggner, P. & Paudel, A., 2 Mai 2018, in : Colloids and Surfaces / B. 168, S. 76-82 6 S.

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

Sulfamerazine
Small Angle Scattering
Simvastatin
Nanostructures
Dermatoglyphics

Detailed modeling and process design of an advanced continuous powder mixer

Toson, P., Siegmann, E., Trogrlic, M., Kureck, H., Khinast, J., Jajcevic, D., Doshi, P., Blackwood, D., Bonnassieux, A., Daugherity, P. D. & am Ende, M. T., 1 Dez 2018, in : International Journal of Pharmaceutics. 552, 1-2, S. 288-300 13 S.

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

Powders
Equipment Design
Equipment and Supplies
Technology

Development of customized 3D printed stainless steel reactors with inline oxygen sensors for aerobic oxidation of Grignard reagents in continuous flow

Maier, M. C., Lebl, R., Sulzer, P., Lechner, J., Mayr, T., Zadravec, M., Slama, E., Pfanner, S., Schmoelzer, C., Poechlauer, P., Kappe, C. O. & Gruber-Wölfler, H., 2018, in : Reaction Chemistry & Engineering.

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

Open Access
3D printers
Oxygen sensors
Optical sensors
Reaction kinetics
Computational fluid dynamics

Effect of Technically Relevant X-Ray Doses on the Structure and Function of Alcohol Dehydrogenase and Hen Egg-White Lysozyme

Khinast, J., Schaden, L-M., Wimmer-Teubenbacher, M., Poms, J., Laggner, P., Lohner, K., Sacher, S. & Salar-Behzadi, S., 2018, in : Pharmaceutical research.

Publikation: Beitrag in einer FachzeitschriftArtikelForschungBegutachtung

EMA : Die Expertise der Apotheker ist gefragt.

Stegemann, S., 1 Jan 2018, in : Österreichische Apotheker-Zeitung. 72, 1, S. 60-62 3 S.

Publikation: Beitrag in einer FachzeitschriftArtikelForschung